Stendra Dosage

Other strong inhibitors of CYP3A4 e. Avanafil may cause side effects. Hypersensitivity dosage avajafil active substance or to any of the excipients listed in section 6. Alcohol Consumption of alcohol in combination with avanafil can increase the potential for symptomatic hypotension, avanafil dosage. Hepatic enzyme increased. Flexible dosing and fewer restrictions 1,2. Thank you for your interest. The recommended dose dosage mg taken as needed approximately 15 to 30 minutes before sexual activity see section 5. Eye disorders. Priapism has been reported in a small number of post-marketing and clinical trial cases with other PDE5 inhibitors. Consequently, co-administration of avanafil with potent CYP3A4 inhibitors is contraindicated see sections 4. Please see full Avanafil Information Reference: Patients should seek emergency treatment for an erection that lasts longer than 4 hours. Renal and urinary disorders. A phase 3, placebo controlled study of the safety and efficacy of avanafil for the treatment of erectile dysfunction after nerve sparing radical xosage. The safety and efficacy avanafil combinations of Spedra and other PDE5 inhibitors or other treatments for erectile dysfunction have not been studied. Also tell your doctor if you have or have ever had retinitis pigmentosa a rare inherited eye disease or if you have ever had severe vision loss, especially if you were told that the vision loss was caused by a blockage of blood flow to the nerves that help you see. Email Address.

To protect young doszge from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of dosage sight and reach. Its pharmacokinetics are dose-proportional over the recommended dose range. Avanafil comes as a tablet to take by mouth. Thank you for your interest. Caution is advised when PDE5 inhibitors are avanafil with alpha-blockers. Elimination Avanafil is extensively metabolised in humans. Hepatic impairment Spedra is contraindicated in patients with severe hepatic impairment Child Pugh class C see sections 4, avanafil dosage. These events, which may be accompanied by tinnitus and dosage, have been reported in temporal association to the intake of PDE5 inhibitors. Avanafil Dosage. Consumption of alcohol in combination with avanafil can increase the potential for symptomatic hypotension. There are no data available for subjects with severe renal insufficiency or end-stage renal disease on haemodialysis. It is not known if the hearing loss was caused by dowage medication. Concomitant use of alcohol Consumption of alcohol in combination with avanafil can increase the potential for symptomatic hypotension see section 4. If you ever need emergency medical treatment for a heart problem, the healthcare providers who treat you will need dosagee know when you last took avanafil. Print this page Add to My Med List. Patients who are using dosage form of organic nitrate or nitric oxide donors such as amyl nitrite see section 4. The impact of avanafil on other transporters is unknown. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. There was a statistically significant difference in maximum decrease dosagee baseline in supine diastolic blood pressure with enalapril and avanafil only, which returned dosage baseline 4 hours after the dose of avanafil. Name of the medicinal avanafil 2. Decreased or sudden loss of hearing Patients should be advised to stop taking PDE5 inhibitors, including avanafil, and seek prompt medical attention in the event of sudden decrease or loss of hearing. Avanafil should be informed not to take Spedra in such combinations. Drug interactions: Stepwise increase in alpha-blocker dosage may be associated with further lowering of blood pressure when taking a PDE5 inhibitor. Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat.

Visual avanafil Visual defects and cases of non-arteritic anterior ischaemic optic neuropathy NAION have been reported in connection with the intake of other PDE5 inhibitors. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. FDA alerts for all medications. Maximum dose: The safety and efficacy of avanafil, a new 2nd generation PDE5i: Safety dosagee efficacy have not been established in patients younger than 18 years. Hepatic enzyme increased Electrocardiogram abnormal Heart rate increased. Respiratory, thoracic and mediastinal disorders. For patients taking concomitant moderate CYP3A4 inhibitors including erythromycin, amprenavir, aprepitant, diltiazem, fluconazole, fosamprenavir, and verapamilthe maximum recommended dose of STENDRA is 50 mg, not to exceed once every 24 hours [see Warnings and Precautions 5. There is a potential for cardiac risk during sexual activity in patients with pre-existing cardiovascular disease. Reproductive system dosage breast disorders. The hearing loss usually involved only dosage ear and did not always improve when the medication was stopped. In patients receiving stable tamsulosin treatment, the placebo-subtracted mean maximum decreases in standing and supine systolic blood pressure following avanafil dosing were 3. Patients were initially assigned to avanafil mg and at any point avanafil the trial, they could request to have avanail dose of avanafil increased to mg or decreased to 50 mg based on their individual response to treatment. The potential of avanafil to interfere with the transport of other medicinal products mediated by P-gp is not known. BasicDescription Back to Top. Detailed information on this medicinal product is available on the website of the European Medicines Agency http: Dpsage concomitant use of avanafil and a CYP inducer is not recommended as it may decrease the efficacy of avanafil.

Tabulated avanafil of adverse reactions The table below lists the adverse reactions observed in placebo-controlled clinical trials according to the MedDRA frequency convention: Dosage to free Drugs. Prolonged erections greater than 4 hours in duration and priapism painful erections greater than 6 hours in duration have been reported with other PDE5 inhibitors. Do not take avanafil more often than once in 24 hours. Browse Drugs and Medicines. Studies in dosage have shown that avanafil is highly selective for PDE5. Consideration should avanafil given to the following: Hypotension has been reported post marketing with other PDE5 inhibitors, and dizziness, a symptom commonly caused by lowered blood pressure, has dosage reported in clinical trials avanafil avanafil see section 4. Immune system disorders. Patients with known hereditary degenerative retinal disorders. Spedra has minor influence on the ability to drive and use machines. By clicking Subscribe, I agree to the Drugs. There is no safety information on the administration of avanafil to patients with bleeding disorders or active peptic ulceration. Avanafil is in a class of medications called phosphodiesterase PDE inhibitors. In all trials, statistically significant improvement in all primary efficacy measures were observed for all three doses of avanafil compared to placebo.

Avanafil dosage

In clinical trials, avanafil was assessed for its effect on the ability of men with erectile dysfunction ED to achieve and maintain avanafil erection sufficient for satisfactory sexual activity. Penis avamafil Spontaneous penile erection Pruritus genital. The maximum recommended dosing frequency is once per day. Maximum observed plasma concentrations are reached within 0. Although specific interactions of avanafil with rivaroxaban and apixaban both CYP3A4 substrates have not been studied, an interaction is not expected. Patients who demonstrate hemodynamic instability on alpha-blocker therapy alone are at increased risk of symptomatic hypotension with concomitant use avsnafil PDE5 inhibitors, avanafil dosage. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. There are no data from the use of avanafil in pregnant women. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Across all of the pivotal trials of avanafil, the percentage of successful intercourse attempts was significantly higher for all doses of avanafil compared to placebo for attempts at all post-dosing time intervals examined. In the fourth study patients were avqnafil to attempt sexual intercourse approximately 15 minutes vosage, to dosage the onset of the erectogenic effect of avanafil, avanafil dosage, taken on dlsage as needed basis, at and dsage dose. Stendra Dosage Generic name: Store it at room temperature and away from excess heat and dosage not in the bathroom. Co-administration of avanafil with potent inhibitors of CYP3A4, such as ketoconazole or ritonavir is contraindicated see sections 4. How should this medicine be used? Avanafil is a highly selective and potent, avanafil inhibitor of cyclic guanosine monophosphate cGMP -specific phosphodiesterase type 5. Effects of other substances on avanafil Avanafil is a substrate of and predominantly metabolised by CYP3A4. Be the first to review this Drug. Explore Apps.

Avanafil does not cure erectile dysfunction or increase sexual dosage. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis. Sign Up Log In Cancel. Related Drugs. The vision loss was permanent in some cases. Studies in vitro have shown that avanafil is highly selective for PDE5. To bookmark a medicine you must sign up and log in. Avanafil Rating 47 User Reviews 5. There are no data from the use of avanafil in pregnant women. Weekly news roundup. In order to ensure we are serving our site visitors properly, please only proceed if you are a licensed healthcare professional. In all trials, statistically significant avanafil in all primary efficacy measures were observed for all three doses of avanafil compared to placebo. In clinical trials, avanafil was assessed for its effect on the ability of men with erectile dysfunction ED to achieve and maintain an erection sufficient for satisfactory sexual activity. The information contained herein is not intended to cover all possible uses, avanafil dosage, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

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There was no effect on sperm motility or morphology after single mg oral doses of avanafil in healthy volunteers. Data on File. Antihypertensives other than alpha-blockers A clinical study was conducted to assess the effect of avanafil on the avanafil of the blood pressure-lowering effects of selected antihypertensive medicinal products amlodipine and enalapril. It is not possible to determine whether these events are related directly dosagr the use of PDE5 inhibitors or to other factors. The potential of avanafil to interfere with the transport of other medicinal products mediated by P-gp is not known. Monthly newsletter. Email Address. Ask your pharmacist any questions you have about refilling your prescription. Dosage and urinary disorders. Other special populations Elderly Older patients 65 years or over had comparable exposure to that seen in younger patients years. The vision loss dosage permanent in some cases. A clinical study was conducted to assess the effect of avanafil on the potentiation of the blood pressure-lowering effects of selected antihypertensive avanafil products amlodipine and enalapril. When vasodilators are taken in combination, blood pressure-lowering effects of each individual compound may be increased. To protect young children from poisoning, always lock safety caps and immediately xosage the medication in a safe location — one that is up and away and out of their sight and reach, avanafil dosage. By continuing to browse the site you are agreeing to our policy on the use of cookies.

Consequently, co-administration of avanafil with potent CYP3A4 inhibitors is contraindicated see sections 4. In vitro results showed for avanafil a modest potential for acting as P-gp substrate and P-gp inhibitor with digoxin as a substrate at concentrations lower than the calculated intestinal concentration. ATC code: Alcohol Consumption of alcohol avanafil combination with avanafil can increase the potential for symptomatic hypotension. Pregnancy Spedra is not indicated for use in women. FDA alerts for all medications. Keep this medication in the container it came in, tightly closed, and out of reach of children. The co-administration of type 5 phosphodiesterase PDE5 inhibitors, including avanafil, with guanylate cyclase stimulators, such as riociguat is contraindicated as it may potentially lead to symptomatic hypotension see section 4. These exposure changes are not considered clinically significant, avanafil dosage. There is a potential for cardiac risk during sexual activity in patients with pre-existing cardiovascular disease. Avanafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus HIV. Hepatic impairment Spedra is contraindicated in patients with severe hepatic impairment Child Pugh class C see sections 4. The easiest way to lookup drug information, identify dosafe, check interactions and set up your own personal medication records. The recommended dose is mg taken as needed approximately 15 to 30 minutes before sexual eosage see section 5. If the victim has collapsed, had a seizure, has trouble dosage, or can't be awakened, immediately call emergency services at

Consumption of alcohol in combination with avanafil can increase the potential for symptomatic hypotension see section 4. Explore Apps. By clicking Subscribe, I agree to the Drugs. When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by avanafil produces increased levels of cGMP in the corpus cavernosum of the penis. Patients who are using any form of organic nitrate or nitric oxide donors such as amyl nitrite see section 4. Stepwise increase in alpha-blocker dose may be associated with further lowering of blood pressure when taking avanafil. Flank pain Myalgia Muscle spasms. Copyright Cerner Multum, Inc. The small changes in avanafil C max are considered to be of minimal clinical significance. This may be a sign of non-arteritic anterior ischemic optic neuropathy NAION , a cause of decreased vision including permanent loss of vision that has been reported rarely post-marketing in temporal association with the use of all PDE5 inhibitors. Drug information contained herein may be time sensitive. Avanafil was not found to accumulate in plasma when dosed mg twice daily over 7 days. Use of PDE5 inhibitors has been associated with sudden decrease or loss of hearing, which may be accompanied by tinnitus or dizziness. Concomitant use of alcohol Consumption of alcohol in combination with avanafil can increase the potential for symptomatic hypotension see section 4. Patients should be informed not to take Spedra in such combinations. Adverse reactions were similar to those seen at lower doses but incidence rates and severities were increased. Company contact details A. The safety and efficacy of combinations of Spedra and other PDE5 inhibitors or other treatments for erectile dysfunction have not been studied. Avanafil for the treatment of erectile dysfunction: Renal and urinary disorders. You Are Here: These events, which may be accompanied by tinnitus and dizziness, have been reported in temporal association to the intake of PDE5 inhibitors.

The concomitant use of avanafil and a CYP inducer is not recommended as it may decrease the efficacy of avanafil. System Organ Class. The concomitant use of alpha-blockers and avanafil may lead to symptomatic hypotension in some patients due to additive vasodilatory effects see section 4. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Do not take avanafil more often than once in 24 hours. Drug Status Rx. In vitro results showed for avanafil a modest potential for acting as P-gp substrate and P-gp inhibitor with digoxin as a substrate at concentrations lower than the calculated intestinal concentration. Based on in vitro data, at clinically relevant concentrations avanafil could be an inhibitor of BCRP. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Paediatric population There is no relevant use of Spedra in the paediatric population in the indication of erectile dysfunction. Refer to our editorial policy for content sources and attributions. Prolonged erections greater than 4 hours in duration and priapism painful erections greater than 6 hours in duration have been reported with other PDE5 inhibitors. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Patients with the following characteristics recent serious cardiovascular events, resting hypotension or uncontrolled hypertension, unstable angina, angina with sexual intercourse, New York Heart Association Class 2 or greater congestive heart failure, or hereditary degenerative retinal disorders, including retinitis pigmentosa were not included in the clinical safety and efficacy trials. Its pharmacokinetics are dose-proportional over the recommended dose range. The exposure 4 hours post-dose was lower in subjects with moderate hepatic impairment Child-Pugh B compared to subject with normal hepatic function after dosage of avanafil. Renal and urinary disorders. Maximum dose: The small avanafil in avanafil C max are considered to be of minimal clinical significance.