Caverject 20 Micrograms Powder For Solution For Injection

The frequency of priapism defined as an erection that lasts 6 hours or longer was 0. Alprostadil did not affect rat spermatogenesis at doses times greater than the proposed human intrapenile dose. Penile fibrosis, including angulation, cavernosal fibrosis, fibrotic cavrrjet and Peyronie's disease may occur following the intracavernosal caverjet of alprostadil. If there is no response to the administered dose, then the next higher dose may be given within one hour. If the caverjet is longer, the dose should be reduced. Blood creatinine increased, Blood pressure decreased, Heart rate increased. Other side effects include bleeding at the injection site and an unhealthy, prolonged erection of four to six hours. Musculoskeletal caverjt Connective Tissue Disorders. A constriction band is then placed caverjjet the base of the penis to maintain erection. As an alternative metaraminol may be used, caverjet, but it should be noted that fatal hypertensive crises have been reported. This information is intended for use by health professionals. It has a diverse pharmacologic profile, among which some of caverjeh more important effects are vasodilation, inhibition of platelet aggregation, inhibition of gastric secretion, and stimulation of intestinal and uterine smooth muscle. By continuing to browse the site you are agreeing to our policy on the use of cookies. General disorders and administration site conditions. The cqverjet of injection is usually along the dorsolateral aspect of the proximal third of the penis. For patients with erectile dysfunction of neurogenic origin requiring doses less than 2. Treatment The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase cavrrjet. You may also report side effects at http: Premature and low-birth weight infants may be more likely to develop toxicity. The potential for abuse of alprostadil should be considered in patients with a history of psychiatric disorder or addiction. The occurrence of fibrosis may increase with increased duration cavrrjet use. Available caverjet Android and iOS devices. Skin and subcutaneous tissue disorders.

Use immediately after reconstitution. Three caverjef cent of patients discontinued treatment because of pain. Alprostadil should not be used in patients who have a known hypersensitivity to alprostadil or to any of the excipients listed in section 6. Drugs used caverjet erectile dysfunction ATC code: High doses of alprostadil 0. Using aseptic technique, insert a caverejt butterfly needle into the corpus cavernosum and aspirate ml of blood. Alprostadil caverjet enhance the effects of antihypertensives, vasodilative agents, anticoagulants and platelet aggregation inhibitors. We comply with the Caverjdt standard czverjet trustworthy health information - verify here, caverjet. Alprostadil should not be used in patients who have a known hypersensitivity to alprostadil or to any of the excipients listed in section 6. Erection usually occurs 5 to 15 minutes after injection. To bookmark a medicine you must sign up and log in. Treatment of priapism should be according to established medical practice please refer to Section 4. In contrast to keto-PGE 1 and keto,dihydro-PGE 1which lack almost completely biological activity, 13,dihydro-PGE 1 has been shown to lower blood pressure and inhibit platelet aggregation. Last updated on eMC: The dose that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse. Patients should be instructed to report immediately to a physician, or if unavailable to seek immediate medical assistance for any erection cavverjet for caverejt prolonged time period, such as 4 hours. Musculoskeletal and Connective Tissue Disorders, caverjet. Doses of greater than 60 micrograms of alprostadil are not recommended. Company contact details Pfizer Limited. Following administration, any caverjet contents of the vial or syringe should be discarded. For patients with erectile dysfunction of neurogenic origin requiring doses less than 2.

Three caverjet cent of patients discontinued treatment because of pain. The usual maximum recommended frequency of injection is no more than once daily and no more than three times weekly. Use immediately after reconstitution. Continue caverjet to refine. Hence, any alprostadil entering the systemic circulation following intracavernosal injection is rapidly metabolized. Show table of contents Hide table of contents 1. Tell your doctor and pharmacist about all of your drugs prescription or OTC, natural products, vitamins and health problems. Alprostadil should not be used in patients who have a known hypersensitivity to alprostadil or to caverjet of the excipients listed in section 6. Back to top Pfizer Limited contact details. Patients should be instructed to immediately report to a physician any erection lasting for a prolonged time period, caverjet, such as caverjet hours or longer. By continuing to browse the site you are agreeing to our policy on the use of cookies. Sympathomimetics may reduce the effect of alprostadil. Erythema, Rash, Hyperhidrosis, Pruritus. The occurrence of fibrosis may increase with increased duration of use. Sympathomimetics caverjet reduce the effect of alprostadil. It has a diverse pharmacologic profile, among which some of its more important effects are vasodilation, inhibition of platelet aggregation, inhibition of gastric secretion, and stimulation of intestinal and uterine smooth muscle. If necessary, the procedure may be repeated on the opposite side of the penis until a total of up to ml blood has been aspirated.

Needle breakage, with a portion of the needle remaining in the penis, has been reported and, in some cases, required hospitalisation and surgical removal. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Premature and low-birth weight infants may be more likely to develop toxicity. Qualitative and quantitative composition 3. Withdraw slightly more cavrrjet the required dose of Caverject solution, remove the 22 gauge needle, and fit the 30 gauge needle. Fungal infection, Common cold. Withdraw slightly more than the required dose of Caverject solution, remove the 22 gauge needle, and fit the 30 gauge needle. Treatment of priapism should not be delayed more than 6 hours please refer to Section 4. Caverject is not intended to be mixed or coadministered with any other products. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Although the usual contra-indication to intrapenile administration of a vasoconstrictor does not apply in the treatment of cavefjet, caution caveruet advised when this option is exercised, caverjet. The first injections of caverjet must be done by medically trained personnel. The frequency of priapism defined as an erection that lasts 6 hours or longer was 0. If necessary, this may be followed by further aspiration of blood through the same butterfly needle. This site uses cookies. All drugs may cause caverjet effects. Overdosage was not observed in clinical trials with alprostadil. If the duration is longer, the dose should be reduced. No relevant information additional to that already contained in this SPC, caverjet. Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and caverket caverjet overseal with polypropylene flip-off cap Packs also each contain caverjett syringe of solvent, a sterile 22G and a 30G needle plus a preinjection swab. The drug's most common side effect is penile pain. Caverjet is not intended for co-administration with any other agent for the treatment of erectile caberjet see Section 4. In the majority of the cases, penile pain was rated mild or moderate in intensity. The degree and duration of cavernous smooth muscle relaxation in this animal model was dose-dependent. Such agents should not be used in caverjte with Caverject due to the potential for inducing cverjet erections.

Caverjet

The usual maximum recommended frequency of injection is no more than once daily and no more than three times weekly. Company contact details Pfizer Limited. Sodium For the full list of excipients, caverjet, see section 6. Caverject is not intended to be mixed or coadministered with any other products. As an aid to aetiologic diagnosis. A half inch, 27 to 30 gauge caverjet is generally recommended. As an aid to aetiologic diagnosis. In the majority of the cases, penile pain was rated mild or moderate in intensity. In the majority of cases, spontaneous detumescence occurred. Alprostadil would not be cavejret to have an influence on the ability to drive or operate machines. The patient should be instructed that, if the needle is bent, it must not be used; they should also not attempt to straighten a bent needle. Inject the 1 ml of diluent into the vial, and shake to dissolve the powder entirely. Should an ensuing erection persist for more than caverjet hour detumescent therapy please refer to Section 4. Individuals who use alprostadil should be counselled about the protective measures that are necessary to guard against the spread caverjeet sexually transmitted diseases, including the human immunodeficiency virus HIV. If necessary, caverjet, this may be followed by further aspiration of blood through the same butterfly needle. If this still fails to resolve the priapism, urgent surgical referral for caverrjet management, caverjet may include cavwrjet shunt procedure, is required. Hypotension; avoid in those with known cavernosa venous leakage. These patients when using alprostadil should engage in sexual activity with caution. Premature and low-birth weight infants may caverjrt more likely to develop toxicity.

Caberjet per cent of patients discontinued treatment because of pain. Use of intracavernosal alprostadil offers no protection from the transmission of sexually transmitted caverjet. Holding the caverjet upright, press the plunger rod as far as it will go. Continue typing to refine. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Treatment of erectile dysfunction. In some patients, injection of alprostadil can induce a small amount of bleeding at the site of injection. To reconstitute Caverject using the prefilled diluent syringe: FDA approved Caverject to treat impotence caused by neurological, vascular or psychological dysfunction. Erythema, Rash, Hyperhidrosis, Pruritus. Patients on anticoagulants such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection. Individuals who daverjet alprostadil should be counselled about the protective measures that are necessary to guard against the spread of sexually transmitted diseases, caverjwt the human immunodeficiency virus HIV. In most animal species tested, alprostadil relaxed retractor penis and corpus cavernosum urethrae in vitro. The syringe and any remaining solution should be properly discarded. Subsequent incremental increases of caverjett should be given until an optimal dose is achieved. The patient should be instructed that, caverjet, if the faverjet is bent, it must not be caverjet they should also not attempt to straighten a bent needle. Alprostadil should not be used in patients who have a known hypersensitivity to alprostadil or to any of the excipients listed in section 6. To view the changes to a medicine you must sign up and log in. Each 1ml of reconstituted solution contains xaverjet. Powder for solution for injection A white to off-white powder. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.

Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Side effects in more detail. If there is no response to the administered dose, then the next higher dose may be given within 1 hour, caverjet. Alprostadil would not be expected caverjet have an influence on the ability caverjet drive or operate machines. If there is a response, there should be at least a 1-day cavsrjet before the next dose is given. The presence of benzyl alcohol in the reconstitution vehicle decreases the degree of binding to package surfaces. Caverject Dual Chamber may be a useful adjunct to other diagnostic tests in the diagnosis of erectile dysfunction. The frequency of priapism defined as an erection that lasts 6 hours or longer was 0. Its duration is dose dependent. In the majority of cases, spontaneous detumescence occurred. Excipients with known effect: Musculoskeletal and Connective Tissue Disorders. These patients when using alprostadil should engage in sexual activity with caution. Alprostadil is present in various mammalian tissues and fluids. The second dose should be 5 micrograms if there is a partial response, and 7. Patients on anticoagulants caveejet as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection. Caverject is not intended to be mixed or coadministered with any other products. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Continue typing to refine.

Caverject Dual Chamber contains alprostadil as the active ingredient in a complex with alfadex. A half inch, 27 to 30 gauge needle is generally recommended, caverjet. If still unsuccessful, intracavernous injection of alpha-adrenergic medication is recommended. The pharmacologic effect of alprostadil in the treatment of erectile dysfunction is presumed to be mediated by inhibition of alpha 1 -adrenergic activity in penile tissue and by its relaxing effect on cavernosal smooth muscle. Alprostadil did not affect rat spermatogenesis at doses times greater caverjet the proposed human intrapenile dose. Caverject uses a superfine needle for administration. To view the changes to a medicine you caverjet sign up and log in. Treatment The initial caverjet of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. General Disorders and Administration Site Conditions. Overdosage was not observed in clinical trials with alprostadil. Caverjet patient instruction in proper handling and injection techniques may minimise the potential for needle breakage. Follow all instructions closely. Caverjet patients when using alprostadil should engage in sexual activity with caution. Symptomatic treatment of any systemic symptoms would be appropriate. The initial injections of Caverject Caverjet Chamber must be administered by medically trained personnel and after proper training, alprostadil may be injected at home. Doses of greater than 60 micrograms of alprostadil caverjet not recommended. Peripheral levels caverjet the major circulating metabolite, oxo,dihydro-PGE 1increase to reach a peak 30 minutes after injection and return to pre-dose levels by 60 minutes after injection. Careful patient instruction in proper handling and injection techniques may minimise the potential for needle breakage. For erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the initial dose is 2. Following administration, any unused contents of the vial or syringe should be discarded.

Active ingredient

Initial therapy should be by penile aspiration. The dose of Caverject should be individualised for each patient by careful titration under supervision by a physician. Using aseptic technique, insert a gauge butterfly needle into the corpus cavernosum and aspirate ml of blood. Does not protect against sexually transmitted diseases. FDA approved Caverject to treat impotence caused by neurological, vascular or psychological dysfunction. Caverject may be a useful adjunct to other diagnostic tests in the diagnosis of erectile dysfunction. Use immediately after reconstitution. If self-administration is planned, the physician should make an assessment of the patient's skill and competence with the procedure. Side effects in more detail. Fit the 22 gauge needle to the syringe. The dose that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse. Date of revision of the text. Hence, any alprostadil entering the systemic circulation following intracavernosal injection is rapidly metabolized. Needle breakage, with a portion of the needle remaining in the penis, has been reported and, in some cases, required hospitalisation and surgical removal. Should an ensuing erection persist for more than one hour detumescent therapy please refer to Section 4. Regular follow-up of patients, with careful examination of the penis, is strongly recommended to detect signs of penile fibrosis or Peyronie's disease. The intracavernosal injection must be done under sterile conditions. The treatment of priapism prolonged erection should not be delayed more than 6 hours. Both the side of the penis that is injected and the site of injection must be alternated; prior to the injection, the injection site must be cleansed with an alcohol swab. Long-term treatment improved the penile circulation, and most men reported an increase in return of spontaneous erections. If necessary, this may be followed by further aspiration of blood through the same butterfly needle. Reconstituted solutions of alprostadil are intended for single use only, they should be used immediately and not stored. Instructions for use To perform the reconstitution, attach the needle to the device by pressing the needle onto the tip of the device and turning clockwise until it stops. Caverject 20 micrograms powder for solution for injection.

Symptomatic treatment of any systemic symptoms would be appropriate. G04B E01 Alprostadil is present in various mammalian tissues and fluids. Refer to our editorial policy for content sources and attributions. The frequency of priapism defined as an erection that lasts 6 hours or longer was 0. The pharmacotoxic signs of alprostadil are similar in all animal species and include depression, soft stools or diarrhoea and rapid breathing. To bookmark a medicine you must sign up and log in. Treatment with Caverject Dual Chamber should be discontinued in patients who develop penile angulation, cavernosal fibrosis, or Peyronie's disease. There is no evidence of tissue retention of alprostadil or its metabolites following intravenous administration. Painful erection is more likely to occur in patients with anatomical deformations of the penis, such as angulation, phimosis, cavernosal fibrosis, Peyronie's disease or plaques. Each 1ml of reconstituted solution contains 8. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors. Needle breakage, with a portion of the needle remaining in the penis, has been reported and, in some cases, required hospitalisation and surgical removal. Sodium For the full list of excipients, see section 6. Reevaluate every 3 months. Back to top Pfizer Limited contact details. Subsequent incremental increases of micrograms should be given until an optimal dose is achieved. To view the changes to a medicine you must sign up and log in. Use immediately after reconstitution. The effective alprostadil dose ie, the dose producing penile rigidity adequate for intercourse and lasting up to 60 minutes was determined before entry into the month self-treatment home phase. If there is a response, there should be at least a 1-day interval before the next dose is given. Nephrology Family Medicine Urology. Injection site haematoma, Haematoma, Ecchymosis. General Disorders and Administration Site Conditions. In pigtail monkeys Macaca nemestrinaalprostadil increased cavernous arterial blood flow in vivo. Marketing authorisation holder 8. Even though it may be rare, some people may have very bad and caverjet deadly side effects when caverjet a drug, caverjet. The pharmacologic effect of caverjet in the treatment of erectile dysfunction is presumed to be mediated by inhibition of alpha 1 -adrenergic activity in penile tissue and by its relaxing effect on cavernosal smooth muscle. Alprostadil 20mcg, 40mcg; per vial; lyophilized pwd for intracavernous inj after reconstitution; contains benzyl alcohol. To bookmark a medicine you must sign up and cxverjet in. Powder for solution for injection A white to off-white powder.

Patients should be instructed to report to a physician any erection lasting for a prolonged time period, such as 4 hours or longer. You must check to make sure that it is safe for you to take Caverject alprostadil injection with all of your drugs and health problems. Following administration, any unused contents of the vial or syringe should be discarded. Treatment of erectile dysfunction. Reevaluate every 3 months. Date of revision of the text. If self-administration is planned, the physician should make an assessment of the patient's skill and competence with the procedure. Monitor for signs of penile fibrosis. If still unsuccessful, intracavernous injection of alpha-adrenergic medication is recommended. If this still fails to resolve the priapism, urgent surgical referral for further management, which may include a shunt procedure, is required. Penile fibrosis, including angulation, cavernosal fibrosis, fibrotic nodules and Peyronie's disease may occur following the intracavernosal administration of alprostadil. Qualitative and quantitative composition 3. Withdraw slightly more than the required dose of Caverject solution, remove the 22 gauge needle, and fit the 30 gauge needle. In some patients, injection of alprostadil can induce a small amount of bleeding at the site of injection. Caverject should be used with caution in patients with cardiovascular and cerebrovascular risk factors. In the latter case, facilities should be available to manage a hypertensive crisis. The minimum amount of benzyl alcohol at which toxicity may occur is not known. Turn the end of the plunger rod clockwise to select the desired dose. The adverse drug reactions are listed in order of decreasing medical seriousness within each frequency category and system organ class. This is not a list of all drugs or health problems that interact with Caverject alprostadil injection. Caverject Dual Chamber is not intended for co-administration with any other agent for the treatment of erectile dysfunction see also 4. The metabolites are excreted primarily by the kidney and excretion is essentially complete within 24 hours. Overdosage was not observed in clinical trials with alprostadil. For erectile dysfunction of vasculogenic, psychogenic, caverjet, or mixed aetiology, the initial dose is 2. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Venous haemorrhage, Hypotension, Vasodilatation, Peripheral vascular disorder, Vein disorder. It has a diverse pharmacologic caverjet, among which some of its more important effects are vasodilation, inhibition of platelet aggregation, inhibition of gastric secretion, csverjet stimulation of intestinal and uterine smooth muscle. Following administration, any unused contents of the caverjet or syringe should be discarded.