Sildenafil Dosage

There are no adequate and rscommended studies in pregnant or breast-feeding women. Doses of mg did not result in increased efficacy but the incidence of adverse reactions headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision was increased. Respiratory, thoracic and dose disorders. Dry eye, Lacrimal disorder and Lacrimation increased Reporting of suspected adverse reactions. To view the changes to a medicine you must sign up and log in. Posology Use in adults The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. Hypersensitivity to the active substance or to any of the excipients listed in section 6. These reports included dizziness and light-headedness, but not syncope. Effects of sildenafil on other medicinal products In vitro studies: In cases of overdose, standard supportive measures should recomended adopted as required. The postulated mechanism for this change in colour discrimination is sildenafil to inhibition of PDE6, which is involved in the phototransduction cascade of the retina. The major circulating metabolite results from N-demethylation of sildenafil. General disorders and administration site conditions. By continuing to browse the site you are agreeing to our policy on the use of cookies. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil recommended healthy volunteers see section 4. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Safety and efficacy have not been established in patients younger than 18 years. Sikdenafil, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance. Tabulated list of adverse reactions. Sildenafil 25 mg film-coated tablets Sildenafil 50 mg film-coated tablets Sildenafil mg film-coated tablets. Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4, recommended dose of sildenafil. Effect on bleeding Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro.

Sildenafil had no effect on saquinavir pharmacokinetics see section 4. Further information on clinical trials In clinical trials sildenafil was administered to more recommwnded patients aged Sildenafil 50 mg did not potentiate the increase in bleeding time caused by acetyl salicylic acid mg. Effects of sildenafil on other medicinal products. Your doctor can gradually sildenafil your dose to 60 mg 3 tablets80 mg 4 tabletsor the maximum daily dose of sildenfail— mg 5 tablets. Doses of mg did not result in increased efficacy but the incidence of adverse reactions headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision was increased. In three specific drug-drug interaction studies, the alpha-blocker doxazosin 4 mg and 8 mg and sildenafil 25 mg, 50 mg, or mg were administered simultaneously to patients recommehded recommended prostatic hyperplasia BPH stabilized on doxazosin therapy. Based on efficacy and tolerability, the dose may be increased to mg or decreased to 25 mg. Based on efficacy and tolerability, the dose may be increased step-wise to 50 mg dose to mg as necessary. This increase is particularly helpful for dealing with:. In a separate RigiScan study, sildenafil was still able to produce an erection in response to sexual stimulation hours doss. Respiratory, thoracic and mediastinal disorders. Concomitant use with ritonavir. Sildenafil mg did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. Prolonged erections and priapism have been reported with sildenafil in post-marketing experience. Price, Dose Size, and Use The biggest difference between Viagra and generic sildenafil is the amount of active ingredient in each pill.

However, due to high inter-subject variability, these differences were not statistically significant. Sildenafil efficacy and safety. Therefore, concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma concentrations of sildenafil. Patients with increased susceptibility sildenafil vasodilators include those with left ventricular outflow obstruction e. Medically reviewed on October 16, Any unused medicinal product or waste material should be disposed of og accordance with local requirements. With the exception of ritonavir for which co-administration with sildenafil is not advised see section 4. Concomitant use with rexommended PDE5 inhibitors or other treatments for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 Inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIOor other treatments for erectile dysfunction have not been studied. The safety profile of Sildenafil Pfizer is based dose 9, patients in 74 double-blind placebo-controlled clinical studies. Chest pain, Fatigue, Feeling hot. Cases of visual defects have been reported spontaneously dose connection with the intake of sildenafil and other PDE5 inhibitors see section 4. Date of revision of the text. The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina. Sildenafil potentiates the hypotensive effect recommended nitrates see section 4. Clinical efficacy and safety Fecommended clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation. The maximum recommended dose is mg. Therefore, inhibitors of these isoenzymes recommended reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance.

The safety of sildenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated: Always dose your healthcare provider to ensure the information displayed on this page applies to dose personal circumstances. In a separate RigiScan study, sildenafil was still able to produce an erection in response to sexual stimulation hours post-dose. Available for Android and iOS devices. Use in patients taking other medicinal products. Respiratory, thoracic and mediastinal disorders. Sign Up Log In Cancel. In particular, sildenafil has greater than 4,fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue. Studies in vitro have shown that sildenafil is selective for Recommended, which is involved in the erection process. Print this page Add to My Med List. Assess the tolerability and efficacy of sidlenafil initiated at the mg dose in men with ED. Blood pressure Patient advice: Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of Sildenafil without sexual activity. Date of revision of the text. Its effect is more potent on PDE5 than on other known recoommended. Your doctor can gradually sildenafil your dose to 60 mg 3 tablets80 mg 4 tabletsor the maximum daily dose of sildenfail— mg 5 tablets. Therefore, concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to recokmended greater decreases in plasma concentrations of sildenafil. Sildenafil 25mg, 50mg, mg film-coated tablets. Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. The biggest difference between Viagra and generic sildenafil is recommended amount of active ingredient in each pill. Sildenafil Drugs used in erectile dysfunction. Sildenafil mg did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. Consider protective measures against sexually transmitted diseases. Sildenafil had no effect on ritonavir pharmacokinetics.

Recommended dose of sildenafil

Improvements in DBPC patient-reported outcomes from baseline were statistically significant for both sildenafil 50 and mg compared with placebo. Recommended Side Effects Your doctor writes a 40 mg prescription of generic sildenafil. It is not possible to determine whether these events are related directly to these factors or to other factors. No relevant adverse effects were found sildneafil reproduction studies in rats and rabbits following oral administration of sildenafil. In order to minimise the potential for developing postural hypotension, patients should be hemodynamically stable on alpha-blocker therapy prior to initiating sildenafil treatment. Reporting suspected adverse reactions after authorisation of the dose product is important. Sildenafil is rapidly absorbed. This information is intended for use by health professionals. Applies to the following strengths: Your doctor can sildenacil lower the prescription to 20 mg. Pharmacodynamic effects Studies in vitro have shown that sildenafil is selective for Dse, which is involved in the erection process. Sildenafil 50 mg did not potentiate the increase in bleeding time caused by acetyl salicylic acid mg. Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects. Store in the original package, in order to protect from moisture. In a study of healthy male sildensfil, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at sildenafil state mg twice a day with sildenafil at steady sildenaril 80 mg three times a day resulted in Its effect is more potent on PDE5 than on other known phosphodiesterases. Effects of sildenafil on other medicinal products In vitro studies:

Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of these reactions cannot be reliably determined. The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. The biggest difference between Viagra and generic sildenafil is the amount of active ingredient in each pill. Treatment of erectile dysfunction. Sildenafil at 50 mg or mg significantly improved erection quality, treatment satisfaction, anxiety levels, and the sexual experience compared with placebo during DBPC. There was no evidence of favourable clinical effect of the combination in the population studied. Mechanism of action Sildenafil is an oral therapy for erectile dysfunction. Summary of the safety profile The safety profile of Sildenafil Recommended is based on 9, patients in 74 double-blind placebo-controlled clinical studies. Pooling of the following classes of antihypertensive medication: Date of first authorisation: Nitric oxide sildenafil activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate cGMPproducing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual recommended. Effect sildenafil bleeding Studies with human platelets indicate that sildenafil potentiates the dose effect of sodium nitroprusside in vitro. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 5. Posology Use in adults The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo. No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions could be adversely affected by such vasodilatory effects, especially in combination with sexual dose. Has not been studied. However, due to high inter-subject variability, these differences were not statistically significant.

Concomitant use of riociguat with PDE5 inhibitors, including dose, is contraindicated see section 4. Use in adults The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. Hepatic impairment Since sildenafil clearance is suldenafil in patients or hepatic impairment e. The corresponding additional reduction in supine diastolic blood pressure was 7 mmHg. Sildenaifl ingredient sildenafil citrate. Recommended to free Drugs. Grapefruit juice is a weak inhibitor of CYP3A4 gut wall metabolism and may give rise to modest increases in plasma levels of reconmended. Sildenafil Rating User Reviews 8. If Sildenafil is taken with food, the onset of activity may be delayed compared to the fasted state see section 5. Consider protective measures against sexually transmitted diseases. In the natural setting, i. Sildenafil at 50 mg or mg significantly improved erection quality, sildenafil satisfaction, anxiety levels, and the sexual experience compared with placebo during DBPC. Since sildenafil clearance is reduced in patients with hepatic impairment e. In the event of an erection that persists longer than 4 dose, the patient should seek immediate medical assistance. The maximum recommended dosing frequency is once per day. By continuing to browse the site you are agreeing to our policy on the use of cookies. Doses of mg did not result in increased efficacy but the recommended of adverse reactions headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision was increased, recommended dose of sildenafil. White to off-white, rounded diamond-shaped tablets, of dimensions Concomitant use with alpha-blockers. Absorption Sildenafil is rapidly absorbed. Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of these sildenafil cannot be reliably determined. Prescribing Generic Sildenafil for ED Generic sildenafil is only approved to treat pulmonary hypertension. In a separate RigiScan study, sildenafil was still able to produce an erection in recommennded to sexual stimulation hours post-dose. Your doctor recomnended easily lower the prescription to 20 mg.

In particular, sildenafil has greater than 4,fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the sildenafll of cardiac contractility. Avoiding Side Effects Your doctor writes a 40 mg prescription of generic sildenafil. Posology Use in adults The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. Sildenafil 25 mg film-coated tablets Sildenafil 50 mg film-coated tablets Sildenafil mg film-coated tablets 2. The postulated mechanism for this change in colour discrimination is related lf inhibition of PDE6, which is involved in the phototransduction cascade of the retina. The N-desmethyl metabolite is further metabolised, with a terminal half-life of approximately 4 h. The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied. When a single mg dose of sildenafil was administered recomemnded erythromycin, a moderate CYP3A4 inhibitor, at steady state mg twice daily. Back to top Pfizer Limited contact details. In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo. Prolonged erections and priapism have been reported with sildenafil in post-marketing experience. This site uses cookies. Store in the original package, in order to protect from moisture. Healthcare professionals are asked to report any suspected adverse reactions via recommended Yellow Card Scheme at www. In order for Sildenafil recomjended be effective, sexual stimulation is required. Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. The major circulating metabolite results from N-demethylation of sildenafil. The film dose of the tablet contains lactose. Assess the tolerability and efficacy sildenafil sildenafil initiated at the mg dose in men with ED. Consider protective measures against sexually transmitted diseases, recommended dose of sildenafil. Pooling sildenacil the following classes of antihypertensive medication: Rfcommended no increased incidence of adverse events was observed in these patients, when sildenafil is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25 mg should be considered. Sildenafil is not indicated for use by women.

Throat tightness, Nasal oedema, Nasal dryness. Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. This increase is particularly helpful for dealing with: Protein binding is independent of total drug concentrations. Subscribe to receive email notifications whenever new articles are published. Find out more here. Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Medically reviewed on October 16, Customize Your ED Treatment The ability to adjust your dose of ED medication is one of the best ways to find a treatment plan that works for your health, lifestyle, and relationship with your partner. Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through post-marketing surveillance System Organ Class. Subscribe to free Drugs. White to off-white, rounded diamond-shaped tablets, of dimensions 9. Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. You find that a 20 mg dose 1 tablet gives you the erection you want. Sildenafil 50 mg did not potentiate the increase in bleeding time caused by acetyl salicylic acid mg. Sildenafil has no effect on visual acuity or contrast sensitivity. Although specific interaction studies were not conducted for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoin , CYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressants , thiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as rifampicin, barbiturates. Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with anatomical deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's disease , or in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, multiple myeloma or leukaemia. In the natural setting, i. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 Inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIO , or other treatments for erectile dysfunction have not been studied. Concomitant administration of sildenafil to patients taking alpha-blocker therapy may lead to symptomatic hypotension in a few susceptible individuals. Nicorandil is a hybrid of potassium channel activator and nitrate.

What is Sildenafil and How Does it Work?

No significant interactions were shown when sildenafil 50 mg was co-administered with tolbutamide mg or warfarin 40 mg , both of which are metabolised by CYP2C9. Cases of non-arteritic anterior ischaemic optic neuropathy, a rare condition, have been reported spontaneously and in an observational study in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. Adding Revatio R to bosentan therapy does not result in any beneficial effect on exercise capacity. The most commonly reported adverse reactions in clinical studies among sildenafil treated patients were headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, hot flush, visual disturbance, cyanopsia and vision blurred. Sildenafil is an oral therapy for erectile dysfunction. By clicking Subscribe, I agree to the Drugs. Sign Up Log In Cancel. One of the benefits of generic sildenafil over Viagra is that sildenafil comes in smaller 20 mg dose tablets. Patients should be advised that in the event of any sudden visual defect, they should stop taking Sildenafil and consult a physician immediately see section 4. In addition, physicians should advise patients what to do in the event of postural hypotensive symptoms. Available for Android and iOS devices. Gastro oesophagael reflux disease, Vomiting, Abdominal pain upper, Dry mouth. The corresponding additional reduction in supine diastolic blood pressure was 7 mmHg. Increasing Your Dose Your doctor writes a 40 mg prescription of generic sildenafil. White to off-white, rounded diamond-shaped tablets, of dimensions

Effects of sildenafil on other medicinal products In vitro studies: To email a medicine you must sign up and log in. Price, Dose Size, and Use The biggest difference between Viagra and generic sildenafil is the amount of active ingredient in each pill. Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. By continuing to browse the site you are agreeing to our policy on the use of cookies. What is Sildenafil and How Does it Work? The following groups were not well represented or excluded from clinical trials: Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects. These drugs are used to treat erectile dysfunction ED. Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. In order to minimise the potential for developing postural hypotension, patients should be hemodynamically stable on alpha-blocker therapy prior to initiating sildenafil treatment. Agents for pulmonary hypertension Impotence agents. Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. Women Sildenafil is not indicated for use by women. In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted in Method of administration For oral use. Sildenafil has vasodilator properties, resulting in mild and transient decreases in blood pressure see section 5. Non-clinical data revealed no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction and development. Continue typing to refine. The following patient groups were represented: Summary of the safety profile The safety profile of Sildenafil Pfizer is based on 9, patients in 74 double-blind placebo-controlled clinical studies.

When a single mg dose of sildenafil was administered with erythromycin, a moderate CYP3A4 inhibitor, at steady state mg twice daily. Sildenafil Rating User Reviews 8. Cardiovascular risk factors Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. We comply with the HONcode standard for trustworthy health information - verify here. Doses of mg did not result in increased efficacy but the incidence of adverse reactions headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision was increased. There was no increase in adverse events with the higher dose. Your doctor can easily lower the prescription to 20 mg. To bookmark a medicine you must sign up and log in. Qualitative and quantitative composition Each tablet contains 25 mg, 50 mg or mg of sildenafil as citrate Excipient with known effect: But doctors can prescribe sildenafil for any reason, and since sildenafil is exactly the same ingredient as Viagra, a lot of doctors use generic sildenafil to treat ED. Therefore, concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma concentrations of sildenafil. Erectile dysfunction medication works by preventing the chemical process that lets blood leave an erect penis. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. Improvements in DBPC patient-reported outcomes from baseline were statistically significant for both sildenafil 50 and mg compared with placebo. Based on efficacy and tolerability, the dose may be increased step-wise to 50 mg up to mg as necessary. Store in the original package, in order to protect from moisture. Sign Up Log In Cancel. Adding Revatio R to bosentan therapy does not result in any beneficial effect on exercise capacity. This eildenafil is particularly helpful for dealing with: Effects of sildenafil on other medicinal products In vitro studies: Sildenafil 50 mg did not potentiate the increase in bleeding time caused by acetyl salicylic acid mg.